It is advisable to have the computer to not go on sleep mode or to not turn on screensaver so that it can perform a scan. That is because if the PC is on sleep mode or when the screensaver activates, everything in the background stops.
For that, just disable screensaver for the Trend Micro program to perform a scheduled scan.
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I like to advice you, to let your off the screensaver and just let the screen go off, no use of a screensaver anymore, it was mend for protection your screen (burning in) but it is useless since the LCD screens are in use, better is to put off the screen after 15 minutes when you don't use the PC!