Thank you for contacting here! For your question, we are sorry to inform you that the Scan feature of Trend Micro Security doesn’t support .pst file currently. However, we confirm with our product development team, when you download the store copies (emails or other items) of .pst file, Trend Micro Security will Perform real-time scan automatically.
Please let me know if you have more concerns or questions by replying here. Thank you.