Hi @cat54843, thanks for being a loyal Trend Micro product customer!
To answer your question, this "SafeGuard Google Chrome" means please enable your Trend Micro ToolBar on your Google Chrome Browser. It's highly recommended that you enable it. We have a support article about this message that should help you: Enabling the Trend Micro Toolbar in Google Chrome
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Do not enable the Trend Micro Toolbar for Google Chrome. The proxy server will not resolve if the toolbar is enabled. I had to disable Trend Micro then disable the toolbar in Chrome to get Chrome to load.