Normally, replacing motherboard will not affect existing installed programs. Do you see error messages asking you to turn on security / virus protection? Trend Micro Maximum Security automatically starts when Windows starts. If it does not auto start, please try the following solution to troubleshoot and turn on protection: Trend Micro Titanium does not start or turn on
Let us know if the solution resolves your issue, and we'll assist you if you still encounter problems. Thank you.