Hello, dap1952. Welcome to the Home Users Community!
Yes, the Trend Micro program is an antivirus program and should be able to prevent malware infection. You mentioned that ByteFence detected a malicious file or program, can we ask for any information about that? Sending a screenshot of the notice may help.
It's possible that ByteFence detected a grayware or an adware (not an actual malware but gives annoying pop ups; sometimes misleading).