Just bought and paid for latest greatest from trend Micro but when I try to download same I get message saying my Windows Vista set-up is not compatible with it. Sent to Microsoft site and up graded my browser but still can't download.
Thanks for posting your concern here and welcome to the community!
Regarding your concern, Trend Micro has already released an official statementregarding its End-of-Support for Windows Vista. It is recommended that you upgrade your operating system in order for it to be compatible with Trend Micro's latest version of the software.
Should you refuse to upgrade your OS, you can still install Trend Micro onto your Vista but you would have to install an earlier version.